Structural Basis for the Regulation of the Mitogen-activated Protein (MAP) Kinase p38α by the Dual Specificity Phosphatase 16 MAP Kinase Binding Domain in Solution

Mitogen-activated protein kinases (MAPKs) fulfill essential biological functions and are key pharmaceutical targets. Regulation of MAPKs is achieved via a plethora of regulatory proteins including activating MAPKKs and an abundance of deactivating phosphatases. Although all regulatory proteins use a...

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Autores principales: Kumar, Ganesan Senthil, Zettl, Heiko, Page, Rebecca, Peti, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784751/
https://ncbi.nlm.nih.gov/pubmed/23926106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499178
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