Prefoldin Plays a Role as a Clearance Factor in Preventing Proteasome Inhibitor-induced Protein Aggregation

Prefoldin is a molecular chaperone composed of six subunits, PFD1–6, and prevents misfolding of newly synthesized nascent polypeptides. Although it is predicted that prefoldin, like other chaperones, modulates protein aggregation, the precise function of prefoldin against protein aggregation under p...

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Bibliographic Details
Main Authors: Abe, Akira, Takahashi-Niki, Kazuko, Takekoshi, Yuka, Shimizu, Takashi, Kitaura, Hirotake, Maita, Hiroshi, Iguchi-Ariga, Sanae M. M., Ariga, Hiroyoshi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784693/
https://ncbi.nlm.nih.gov/pubmed/23946485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476358
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