Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature chaperone complex with Hsp90 that prevents tau degradation. In this study, we have shown that tau levels are r...

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Détails bibliographiques
Auteurs principaux: Blair, Laura J., Nordhues, Bryce A., Hill, Shannon E., Scaglione, K. Matthew, O’Leary, John C., Fontaine, Sarah N., Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L., Muschol, Martin, Uversky, Vladimir N., Klengel, Torsten, Binder, Elisabeth B., Kayed, Rakez, Golde, Todd E., Berchtold, Nicole, Dickey, Chad A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784538/
https://ncbi.nlm.nih.gov/pubmed/23999428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69003
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