Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila

Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several kinases and phosphatases such as Protein Phosphatase-2A (PP2A) and Protein Phospha...

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Detalhes bibliográficos
Principais autores: Garbe, David S., Fang, Yanshan, Zheng, Xiangzhong, Sowcik, Mallory, Anjum, Rana, Gygi, Steven P., Sehgal, Amita
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784489/
https://ncbi.nlm.nih.gov/pubmed/24086144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003749
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