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Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila

Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several kinases and phosphatases such as Protein Phosphatase-2A (PP2A) and Protein Phospha...

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Bibliografiske detaljer
Main Authors: Garbe, David S., Fang, Yanshan, Zheng, Xiangzhong, Sowcik, Mallory, Anjum, Rana, Gygi, Steven P., Sehgal, Amita
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784489/
https://ncbi.nlm.nih.gov/pubmed/24086144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003749
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