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Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin

Insulin-dependent translocation of glucose transporter 4 (Glut4) to the plasma membrane of fat and skeletal muscle cells plays the key role in postprandial clearance of blood glucose. Glut4 represents the major cell-specific component of the insulin-responsive vesicles (IRVs). It is not clear, howev...

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Detalhes bibliográficos
Main Authors: Huang, Guanrong, Buckler-Pena, Dana, Nauta, Tessa, Singh, Maneet, Asmar, Agnes, Shi, Jun, Kim, Ju Youn, Kandror, Konstantin V.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784384/
https://ncbi.nlm.nih.gov/pubmed/23966466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-10-0765
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