Mapping cis- and trans-regulatory effects across multiple tissues in twins

Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many eQTL studies typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues...

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Detalhes bibliográficos
Main Authors: Grundberg, Elin, Small, Kerrin S., Hedman, Åsa K., Nica, Alexandra C., Buil, Alfonso, Keildson, Sarah, Bell, Jordana T., Yang, Tsun-Po, Meduri, Eshwar, Barrett, Amy, Nisbett, James, Sekowska, Magdalena, Wilk, Alicja, Shin, So-Youn, Glass, Daniel, Travers, Mary, Min, Josine L., Ring, Sue, Ho, Karen, Thorleifsson, Gudmar, Kong, Augustine, Thorsteindottir, Unnur, Ainali, Chrysanthi, Dimas, Antigone S., Hassanali, Neelam, Ingle, Catherine, Knowles, David, Krestyaninova, Maria, Lowe, Christopher E., Di Meglio, Paola, Montgomery, Stephen B., Parts, Leopold, Potter, Simon, Surdulescu, Gabriela, Tsaprouni, Loukia, Tsoka, Sophia, Bataille, Veronique, Durbin, Richard, Nestle, Frank O., O’Rahilly, Stephen, Soranzo, Nicole, Lindgren, Cecilia M., Zondervan, Krina T., Ahmadi, Kourosh R., Schadt, Eric E., Stefansson, Kari, Smith, George Davey, McCarthy, Mark I., Deloukas, Panos, Dermitzakis, Emmanouil T., Spector, Tim D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784328/
https://ncbi.nlm.nih.gov/pubmed/22941192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2394
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