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Normal mucus formation requires cAMP-dependent HCO(3)(−) secretion and Ca(2+)-mediated mucin exocytosis
Evidence from the pathology in cystic fibrosis (CF) and recent results in vitro indicate that HCO(3)(−) is required for gel-forming mucins to form the mucus that protects epithelial surfaces. Mucus formation and release is a complex process that begins with an initial intracellular phase of synthesi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784200/ https://ncbi.nlm.nih.gov/pubmed/23818690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.257436 |
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