The Metal-Drug Synergy: New Ruthenium(II) Complexes of Ketoconazole are Highly Active against Leishmania major and Trypanosoma cruzi and Non-toxic to Human or Murine Normal Cells

In our ongoing search for new metal-based chemotherapeutic agents against leishmaniasis and Chagas disease, six new ruthenium-ketoconazole (Ru-KTZ) complexes have been synthesized and characterized, including two octahedral coordination complexes cis-fac-[Ru(II)Cl(2)(DMSO)(3)(KTZ)] (1) and cis-[Ru(I...

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Autori principali: Iniguez, Eva, Sánchez, Antonio, Vasquez, Miguel A., Martínez, Alberto, Olivas, Joanna, Sattler, Aaron, Sánchez-Delgado, Roberto A., Maldonado, Rosa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783607/
https://ncbi.nlm.nih.gov/pubmed/23881220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-013-1024-2
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