Searching for New Chemotherapies for Tropical Diseases: Ruthenium-Clotrimazole Complexes Display High in vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammalian Cells

Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, cis,fac-[Ru(II)Cl(2)(DMSO)(3)(CTZ)] (1), cis,cis,trans-[Ru(II)Cl(2)(DMSO)(2)(CTZ)(2)] (2), Na[Ru(III)Cl(4)(DMSO)(CTZ)] (3) and Na[trans-Ru(III)Cl(4)(CTZ)(2)] (4), [Ru(II)(η(6)-p-cymene)Cl(2)(C...

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Main Authors: Martínez, Alberto, Carreon, Teresia, Iniguez, Eva, Anzellotti, Atilio, Sánchez, Antonio, Tyan, Marina, Sattler, Aaron, Herrera, Linda, Maldonado, Rosa A., Sánchez-Delgado, Roberto A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375397/
https://ncbi.nlm.nih.gov/pubmed/22448965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300070h
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