Searching for New Chemotherapies for Tropical Diseases: Ruthenium-Clotrimazole Complexes Display High in vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammalian Cells

Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, cis,fac-[Ru(II)Cl(2)(DMSO)(3)(CTZ)] (1), cis,cis,trans-[Ru(II)Cl(2)(DMSO)(2)(CTZ)(2)] (2), Na[Ru(III)Cl(4)(DMSO)(CTZ)] (3) and Na[trans-Ru(III)Cl(4)(CTZ)(2)] (4), [Ru(II)(η(6)-p-cymene)Cl(2)(C...

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Bibliografische gegevens
Hoofdauteurs: Martínez, Alberto, Carreon, Teresia, Iniguez, Eva, Anzellotti, Atilio, Sánchez, Antonio, Tyan, Marina, Sattler, Aaron, Herrera, Linda, Maldonado, Rosa A., Sánchez-Delgado, Roberto A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375397/
https://ncbi.nlm.nih.gov/pubmed/22448965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300070h
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