Searching for New Chemotherapies for Tropical Diseases: Ruthenium-Clotrimazole Complexes Display High in vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammalian Cells

Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, cis,fac-[Ru(II)Cl(2)(DMSO)(3)(CTZ)] (1), cis,cis,trans-[Ru(II)Cl(2)(DMSO)(2)(CTZ)(2)] (2), Na[Ru(III)Cl(4)(DMSO)(CTZ)] (3) and Na[trans-Ru(III)Cl(4)(CTZ)(2)] (4), [Ru(II)(η(6)-p-cymene)Cl(2)(C...

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Main Authors: Martínez, Alberto, Carreon, Teresia, Iniguez, Eva, Anzellotti, Atilio, Sánchez, Antonio, Tyan, Marina, Sattler, Aaron, Herrera, Linda, Maldonado, Rosa A., Sánchez-Delgado, Roberto A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375397/
https://ncbi.nlm.nih.gov/pubmed/22448965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300070h
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