Searching for New Chemotherapies for Tropical Diseases: Ruthenium-Clotrimazole Complexes Display High in vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammalian Cells

Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, cis,fac-[Ru(II)Cl(2)(DMSO)(3)(CTZ)] (1), cis,cis,trans-[Ru(II)Cl(2)(DMSO)(2)(CTZ)(2)] (2), Na[Ru(III)Cl(4)(DMSO)(CTZ)] (3) and Na[trans-Ru(III)Cl(4)(CTZ)(2)] (4), [Ru(II)(η(6)-p-cymene)Cl(2)(C...

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Xehetasun bibliografikoak
Egile Nagusiak: Martínez, Alberto, Carreon, Teresia, Iniguez, Eva, Anzellotti, Atilio, Sánchez, Antonio, Tyan, Marina, Sattler, Aaron, Herrera, Linda, Maldonado, Rosa A., Sánchez-Delgado, Roberto A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375397/
https://ncbi.nlm.nih.gov/pubmed/22448965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300070h
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