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Calpastatin prevents NF-κB mediated hyperactivation of macrophages and attenuates colitis

Calpain enzymes proteolytically modulate cellular function and have been implicated in inflammatory diseases. In this study, we found that calpain levels did not differ between intestinal tissues from inflammatory bowel disease (IBD) patients and healthy controls, but IBD tissues showed increased le...

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Detalhes bibliográficos
Main Authors: Huang, Zhi, Rose, Aaron H., Hoffmann, FuKun W., Hashimoto, Ann S., Bertino, Pietro, Denk, Tobias, Takano, Jiro, Iwata, Nobuhisa, Saido, Takaomi C., Hoffmann, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783572/
https://ncbi.nlm.nih.gov/pubmed/23986533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300972
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