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Engineering unnatural variants of plantazolicin through codon reprogramming

Plantazolicin (PZN) is a polyheterocyclic natural product derived from a ribosomal peptide that harbors remarkable antibiotic selectivity for the causative agent of anthrax, Bacillus anthracis. To simultaneously establish the structure-activity relationship of PZN and the substrate tolerance of the...

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Autori principali: Deane, Caitlin D., Melby, Joel O., Molohon, Katie J., Susarrey, Aziz R., Mitchell, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783559/
https://ncbi.nlm.nih.gov/pubmed/23823732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4003392
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