Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat

Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). The mechanisms underlying the anti-fibrotic effects of carvedilol are unknown. Recent studies have revealed the critical role of microRNAs (miRNAs) in a variety of...

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Detalhes bibliográficos
Main Authors: Zhu, Jie-Ning, Chen, Ren, Fu, Yong-Heng, Lin, Qiu-Xiong, Huang, Shuai, Guo, Lin-Lin, Zhang, Meng-Zhen, Deng, Chun-Yu, Zou, Xiao, Zhong, Shi-Long, Yang, Min, Zhuang, Jian, Yu, Xi-Yong, Shan, Zhi-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783413/
https://ncbi.nlm.nih.gov/pubmed/24086569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075557
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