Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Insulin resistance, tissue inflammation and adipose tissue dysfunction are features of obesity/Type 2 diabetes. Accordingly, we generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knock-out (AKO) mice to investigate the function of NCoR in adipocyte biology and glucose/insulin homeostas...

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Huvudupphovsmän: Li, Pingping, Fan, WuQiang, Xu, Jianfeng, Lu, Min, Yamamoto, Hiroyasu, Auwerx, Johan, Sears, Dorothy D., Talukdar, Saswata, Oh, DaYoung, Chen, Ai, Bandyopadhyay, Gautam, Scadeng, Miriam, Ofrecio, Jachelle M., Nalbandian, Sarah, Olefsky, Jerrold M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783197/
https://ncbi.nlm.nih.gov/pubmed/22078880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.050
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