NCoR REPRESSION OF LXRs RESTRICTS MACROPHAGE BIOSYNTHESIS OF INSULIN-SENSITIZING OMEGA 3 FATTY ACIDS

Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The co-repressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macro...

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Autori principali: Li, Pingping, Spann, Nathanael J., Kaikkonen, Minna U., Lu, Min, Oh, Da Young, Fox, Jesse N., Bandyopadhyay, Gautam, Talukdar, Saswata, Xu, Jianfeng, Lagakos, William S., Patsouris, David, Armando, Aaron, Quehenberger, Oswald, Dennis, Edward A., Watkins, Steven M., Auwerx, Johan, Glass, Christopher K., Olefsky, Jerrold M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131699/
https://ncbi.nlm.nih.gov/pubmed/24074869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.054
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