Characterization of Naturally-Occurring Humoral Immunity to AAV in Sheep

AAV vectors have shown great promise for clinical gene therapy (GT), but pre-existing human immunity against the AAV capsid often limits transduction. Thus, testing promising AAV-based GT approaches in an animal model with similar pre-existing immunity could better predict clinical outcome. Sheep ha...

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Hoofdauteurs: Tellez, Joseph, Van Vliet, Kim, Tseng, Yu-Shan, Finn, Jonathan D., Tschernia, Nick, Almeida-Porada, Graça, Arruda, Valder R., Agbandje-McKenna, Mavis, Porada, Christopher D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782463/
https://ncbi.nlm.nih.gov/pubmed/24086458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075142
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