Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that induce random mutations at the break sites or preci...

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Main Authors: Lo, Te-Wen, Pickle, Catherine S., Lin, Steven, Ralston, Edward J., Gurling, Mark, Schartner, Caitlin M., Bian, Qian, Doudna, Jennifer A., Meyer, Barbara J.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2013
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781963/
https://ncbi.nlm.nih.gov/pubmed/23934893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.155382
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