PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation

Pancreatic duodenal homeobox-1 (Pdx1), a transcription factor required for pancreatic development and maintenance of β-cell function, was assessed for a possible role in postnatal β-cell formation from progenitors in the pancreatic ducts by selectively deleting Pdx1 from the ducts. Carbonic anhydras...

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Autors principals: Guo, Lili, Inada, Akari, Aguayo-Mazzucato, Cristina, Hollister-Lock, Jennifer, Fujitani, Yoshio, Weir, Gordon C., Wright, Christopher V.E., Sharma, Arun, Bonner-Weir, Susan
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781453/
https://ncbi.nlm.nih.gov/pubmed/23775765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1833
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