Constitutive Knockout of Kalirin-7 Leads to Increased Rates of Cocaine Self-Administration

Kalirin-7 (Kal7) is a Rho-guanine nucleotide exchange factor that is localized in neuronal postsynaptic densities. Kal7 interacts with the NR2B subunit of the NMDA receptor and regulates aspects of dendritic spine dynamics both in vitro and in vivo. Chronic treatment with cocaine increases dendritic...

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Detalhes bibliográficos
Main Authors: Kiraly, Drew D., Nemirovsky, Natali E., LaRese, Taylor P., Tomek, Seven E., Yahn, Stephanie L., Olive, M. Foster, Eipper, Betty A., Mains, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781382/
https://ncbi.nlm.nih.gov/pubmed/23894151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087106
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