Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

The effects of inhibition of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways and chemotherapeutic drugs on cell cycle progression and drug sensitivity were examined in cytokine-dependent FL5.12 hematopoietic cells. We examined their effects, as these cells resemble normal hematopoietic precurso...

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Hauptverfasser: Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Chappell, William, Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781183/
https://ncbi.nlm.nih.gov/pubmed/20436269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.9.11544
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