PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches

Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110α subunit of PI3K (PIK3CA)...

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Detalhes bibliográficos
Main Authors: Ligresti, Giovanni, Militello, Loredana, Steelman, Linda S., Cavallaro, Andrea, Basile, Francesco, Nicoletti, Ferdinando, Stivala, Franca, McCubrey, James A., Libra, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2009
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781181/
https://ncbi.nlm.nih.gov/pubmed/19305151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.8.9.8255
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