Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

We report that K5.Smad7 mice, which express Smad7 transgene by a keratin-5 promoter, were resistant to radiation-induced oral mucositis, a painful oral ulceration. In addition to NF-κB activation known to contribute to oral mucositis, we found activated TGF-β signaling in oral mucositis. Smad7 dampe...

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Detalhes bibliográficos
Main Authors: Han, Gangwen, Bian, Li, Li, Fulun, Cotrim, Ana, Wang, Donna, Lu, Jian Bo, Deng, Yu, Bird, Gregory, Sowers, Anastasia, Mitchell, James B., Gutkind, J. Silvio, Zhao, Rui, Raben, David, Dijke, Peter ten, Refaeli, Yosef, Zhang, Qinghong, Wang, Xiao-Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780964/
https://ncbi.nlm.nih.gov/pubmed/23475202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3118
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