Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

Ribosomes are the protein synthesizing factories of the cell, polymerizing polypeptide chains from their constituent amino acids. However, distinct combinations of amino acids, such as polyproline stretches, cannot be efficiently polymerized by ribosomes, leading to translational stalling. The stall...

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Detalhes bibliográficos
Main Authors: Peil, Lauri, Starosta, Agata L., Lassak, Jürgen, Atkinson, Gemma C., Virumäe, Kai, Spitzer, Michaela, Tenson, Tanel, Jung, Kirsten, Remme, Jaanus, Wilson, Daniel N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780873/
https://ncbi.nlm.nih.gov/pubmed/24003132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310642110
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