Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

We report that CNS directed expression of Interferon (IFN) -γ results in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results show that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of...

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Detalhes bibliográficos
Main Authors: Chakrabarty, Paramita, Ceballos-Diaz, Carolina, Lin, Wen-Lang, Beccard, Amanda, Jansen-West, Karen, McFarland, Nikolaus R, Janus, Christopher, Dickson, Dennis, Das, Pritam, Golde, Todd E
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780582/
https://ncbi.nlm.nih.gov/pubmed/21572432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2829
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