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Improved design of prodromal Alzheimer’s disease trials through cohort enrichment and surrogate endpoints
Alzheimer’s disease (AD) trials initiated during or before the prodrome are costly and lengthy because patients are enrolled long before clinical symptoms are apparent, when disease progression is slow. We hypothesized that design of such trials could be improved by: (1) selecting individuals at mod...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779898/ https://ncbi.nlm.nih.gov/pubmed/23629586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-122212 |
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