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Improved design of prodromal Alzheimer’s disease trials through cohort enrichment and surrogate endpoints

Alzheimer’s disease (AD) trials initiated during or before the prodrome are costly and lengthy because patients are enrolled long before clinical symptoms are apparent, when disease progression is slow. We hypothesized that design of such trials could be improved by: (1) selecting individuals at mod...

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Bibliografiske detaljer
Main Authors: Macklin, Eric A., Blacker, Deborah, Hyman, Bradley T., Betensky, Rebecca A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779898/
https://ncbi.nlm.nih.gov/pubmed/23629586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-122212
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