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Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer’s Disease

Age-associated dysregulation of sleep can be worsened by Alzheimer’s disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restr...

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Autors principals: Rothman, Sarah M., Herdener, Nathan, Frankola, Kathryn A., Mughal, Mohamed R., Mattson, Mark P.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779872/
https://ncbi.nlm.nih.gov/pubmed/23856323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.07.010
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