Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

Alzheimer's disease (AD) pathology is estimated to develop many years before detectable cognitive decline. Fluid and imaging biomarkers may identify people in early symptomatic and even preclinical stages, possibly when potential treatments can best preserve cognitive function. We previously re...

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Bibliographic Details
Main Authors: Fagan, Anne M, Mintun, Mark A, Shah, Aarti R, Aldea, Patricia, Roe, Catherine M, Mach, Robert H, Marcus, Daniel, Morris, John C, Holtzman, David M
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806678/
https://ncbi.nlm.nih.gov/pubmed/20049742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900048
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