Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition

There is substantial evidence that cerebrospinal fluid (CSF) levels of both Aβ42 and tau/ptau are promising biomarkers for Alzheimer's disease (AD). We show that both Aβ and tau exhibit more than 10-fold interindividual variation in CSF levels suggesting that these biomarkers may also be effect...

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Bibliografski detalji
Glavni autori: Kauwe, John S. K., Cruchaga, Carlos, Mayo, Kevin, Fenoglio, Chiara, Bertelsen, Sarah, Nowotny, Petra, Galimberti, Daniela, Scarpini, Elio, Morris, John C., Fagan, Anne M., Holtzman, David M., Goate, Alison M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430357/
https://ncbi.nlm.nih.gov/pubmed/18541914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801227105
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