Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

Alzheimer's disease (AD) pathology is estimated to develop many years before detectable cognitive decline. Fluid and imaging biomarkers may identify people in early symptomatic and even preclinical stages, possibly when potential treatments can best preserve cognitive function. We previously re...

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Main Authors: Fagan, Anne M, Mintun, Mark A, Shah, Aarti R, Aldea, Patricia, Roe, Catherine M, Mach, Robert H, Marcus, Daniel, Morris, John C, Holtzman, David M
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806678/
https://ncbi.nlm.nih.gov/pubmed/20049742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900048
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