Human T Cell Activation Results in Extracellular Signal-regulated Kinase (ERK)-Calcineurin-dependent Exposure of Tn Antigen on the Cell Surface and Binding of the Macrophage Galactose-type Lectin (MGL)

The C-type lectin macrophage galactose-type lectin (MGL) exerts an immunosuppressive role reflected by its interaction with terminal GalNAc moieties, such as the Tn antigen, on CD45 of effector T cells, thereby down-regulating T cell receptor signaling, cytokine responses, and induction of T cell de...

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Detalhes bibliográficos
Main Authors: van Vliet, Sandra J., Vuist, Ilona M., Lenos, Kristiaan, Tefsen, Boris, Kalay, Hakan, García-Vallejo, Juan J., van Kooyk, Yvette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779747/
https://ncbi.nlm.nih.gov/pubmed/23918927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471045
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