Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands

The human macrophage galactose-type lectin (MGL) is a C-type lectin characterized by a unique specificity for terminal GalNAc residues present in the tumor-associated Tn antigen (αGalNAc-Ser/Thr) and its sialylated form, the sialyl-Tn antigen. However, human MGL has multiple splice variants, and whe...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Marcelo, Filipa, Supekar, Nitin, Corzana, Francisco, van der Horst, Joost C., Vuist, Ilona M., Live, David, Boons, Geert-Jan P. H., Smith, David F., van Vliet, Sandra J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349122/
https://ncbi.nlm.nih.gov/pubmed/30504228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004957
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