A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor

Receptors for PDGF play an important role in cell proliferation and migration and have been implicated in certain cancers. The 44-amino acid E5 protein of bovine papillomavirus binds to and activates the PDGFβ receptor (PDGFβR), resulting in oncogenic transformation of cultured fibroblasts. Previous...

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Bibliographische Detailangaben
Hauptverfasser: Petti, Lisa M., Talbert-Slagle, Kristina, Hochstrasser, Megan L., DiMaio, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779723/
https://ncbi.nlm.nih.gov/pubmed/23908351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470054
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