Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor

The bovine papillomavirus E5 protein (BPV E5) is a 44-amino-acid homodimeric transmembrane protein that binds directly to the transmembrane domain of the platelet-derived growth factor (PDGF) β receptor and induces ligand-independent receptor activation. Three specific features of BPV E5 are conside...

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Main Authors: Talbert-Slagle, Kristina, Marlatt, Sara, Barrera, Francisco N., Khurana, Ekta, Oates, Joanne, Gerstein, Mark, Engelman, Donald M., Dixon, Ann M., DiMaio, Daniel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Transformation and Oncogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748040/
https://ncbi.nlm.nih.gov/pubmed/19605488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00946-09
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