Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1

Stabilization of the hypoxia-inducible factor (HIF-1) protein extends longevity in Caenorhabditis elegans. However, stabilization of mammalian HIF-1α has been implicated in tumor growth and cancer development. Consequently, for the hypoxic response to benefit mammalian health, we must determine the...

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Bibliographic Details
Main Authors: Leiser, Scott F., Fletcher, Marissa, Begun, Anisoara, Kaeberlein, Matt
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779632/
https://ncbi.nlm.nih.gov/pubmed/23419779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt016
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