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mTOR kinase inhibitors as potential cancer therapeutic drugs
The mammalian target of rapamycin (mTOR) plays a critical role in the positive regulation of cell growth and survival primarily through direct interaction with raptor (forming mTORC complex 1; mTORC1) or rictor (forming mTOR complex 2; mTORC2). The mTOR axis is often activated in many types of cance...
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| 主要作者: | |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779533/ https://ncbi.nlm.nih.gov/pubmed/23792225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.06.017 |
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