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Therapeutic potential of mTOR inhibitors for targeting cancer stem cells

The mammalian target of rapamycin (mTOR) pathway is aberrantly activated in many cancer types. As the intricate network of regulatory mechanisms controlling mTOR activity is uncovered, more refined drugs are designed and tested in clinical trials. While first generation mTOR inhibitors have failed t...

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Foilsithe in:Br J Clin Pharmacol
Main Authors: Francipane, Maria Giovanna, Lagasse, Eric
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061787/
https://ncbi.nlm.nih.gov/pubmed/26609914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12844
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