Independent, Parallel Pathways to CXCL10 Induction in HCV-Infected Hepatocytes

BACKGROUND & AIMS: The pro-inflammatory chemokine CXCL10 is induced by HCV (hepatitis C virus) infection in vitro and in vivo, and is associated with outcome of IFN (interferon)-based therapy. We studied how hepatocyte sensing of early HCV infection via TLR3 (Toll-like receptor 3) and RIG-I (ret...

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Main Authors: Brownell, Jessica, Wagoner, Jessica, Lovelace, Erica S., Thirstrup, Derek, Mohar, Isaac, Smith, Wesley, Giugliano, Silvia, Li, Kui, Crispe, I. Nicholas, Rosen, Hugo R., Polyak, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779522/
https://ncbi.nlm.nih.gov/pubmed/23770038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.06.001
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