Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in constant darkness. Additionally, locomotor acti...

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Autori principali: Bunger, Maureen K., Wilsbacher, Lisa D., Moran, Susan M., Clendenin, Cynthia, Radcliffe, Laurel A., Hogenesch, John B., Simon, M. Celeste, Takahashi, Joseph S., Bradfield, Christopher A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779439/
https://ncbi.nlm.nih.gov/pubmed/11163178
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