The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

We report that MOP3 is a general dimerization partner for a subset of the basic-helix–loop–helix (bHLH)-PER–ARNT–SIM (PAS) superfamily of transcriptional regulators. We demonstrated that MOP3 interacts with MOP4, CLOCK, hypoxia-inducible factor 1α (HIF1α), and HIF2α. A DNA selection protocol reveale...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hogenesch, John B., Gu, Yi-Zhong, Jain, Sanjay, Bradfield, Christopher A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.10.5474
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