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C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)
CCAAT/enhancer-binding protein-β (C/EBPβ) is a mediator of cell survival and tumorigenesis. When C/EBPβ(−/−) mice are treated with carcinogens that produce oncogenic Ras mutations in keratinocytes, they respond with abnormally elevated keratinocyte apoptosis and a block in skin tumorigenesis. Althou...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779322/ https://ncbi.nlm.nih.gov/pubmed/18636078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.105 |
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