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Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
The tumour suppressor ARF is specifically required for p53 activation under oncogenic stress(1–6). Recent studies showed that p53 activation mediated by ARF, but not that induced by DNA damage, acts as a major protection against tumorigenesis in vivo under certain biological settings(7,8), suggestin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737736/ https://ncbi.nlm.nih.gov/pubmed/20208519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08820 |
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