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Reactivating the ARF-p53 axis in AML cells by targeting ULF
The tumor suppressor ARF plays an essential role in the cellular response to oncogenic stress mainly through activation of p53. Nucleophosmin (NPM), a multifunctional protein, forms a stable protein complex with ARF in the nucleolus and protects ARF from the proteasome-mediated degradation. Notably,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3040923/ https://ncbi.nlm.nih.gov/pubmed/20699639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.15.12355 |
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