Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation

Nlrp3 inflammasome activation occurs in response to numerous agonists but the specific mechanism by which this takes place remains unclear. All previously evaluated activators of the Nlrp3 inflammasome induce the generation of mitochondrial reactive oxygen species (ROS), suggesting a model in which...

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Hauptverfasser: Iyer, Shankar S., He, Qiong, Janczy, John R., Elliott, Eric I., Zhong, Zhenyu, Olivier, Alicia K., Sadler, Jeffrey J., Knepper-Adrian, Vickie, Han, Renzhi, Qiao, Liang, Eisenbarth, Stephanie C., Nauseef, William M., Cassel, Suzanne L., Sutterwala, Fayyaz S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779285/
https://ncbi.nlm.nih.gov/pubmed/23954133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.08.001
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