Mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming

The NLRP3 inflammasome is activated in response to microbial and danger signals resulting in caspase-1-dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Canonical NLRP3 inflammasome activation is a two-step process requiring both priming and activation signals. During inflammasom...

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Pubblicato in:J Immunol
Autori principali: Elliott, Eric I., Miller, Alexis N., Banoth, Balaji, Iyer, Shankar S., Stotland, Aleksandr, Weiss, Jerrold P., Gottlieb, Roberta A., Sutterwala, Fayyaz S., Cassel, Suzanne L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916517/
https://ncbi.nlm.nih.gov/pubmed/29602772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701723
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