Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to ensnare and kill invading pathogens, and has been recently termed NETosis. Neutrophils can be stimulat...

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Autors principals: O’Donoghue, Anthony J., Jin, Ye, Knudsen, Giselle M., Perera, Natascha C., Jenne, Dieter E., Murphy, John E., Craik, Charles S., Hermiston, Terry W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779220/
https://ncbi.nlm.nih.gov/pubmed/24073241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075141
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