Deep sequencing of the murine Igh repertoire reveals complex regulation of non-random V gene rearrangement frequencies

A diverse antibody repertoire is formed through the rearrangement of V, D, and J segments at the immunoglobulin heavy chain (Igh) loci. The C57BL/6 murine Igh locus has over 100 functional V(H) gene segments that can recombine to a rearranged DJ(H). While the non-random usage of V(H) genes is well d...

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Detalhes bibliográficos
Main Authors: Choi, Nancy M., Loguercio, Salvatore, Verma-Gaur, Jiyoti, Degner, Stephanie C., Torkamani, Ali, Su, Andrew I., Oltz, Eugene M., Artyomov, Maxim, Feeney, Ann J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778908/
https://ncbi.nlm.nih.gov/pubmed/23898036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301279
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