Germline deletion of Igh 3′ regulatory region elements hs5-7 affects B cell specific regulation, rearrangement and insulation of the Igh locus()

Regulatory elements located within a ~28 kb region 3′ of the Igh gene cluster (3′ regulatory region, 3′ RR) are required for class switch recombination and for high levels of IgH expression in plasma cells. We previously defined novel DNase I hypersensitive (hs) sites, i.e. hs5-7, immediately downst...

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Main Authors: Volpi, Sabrina A., Verma-Gaur, Jiyoti, Hassan, Rabih, Ju, Zhongliang, Roa, Sergio, Chatterjee, Sanjukta, Werling, Uwe, Hou, Harry, Will, Britta, Steidl, Ulrich, Scharff, Matthew, Edelman, Winfried, Feeney, Ann J., Birshtein, Barbara K.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430471/
https://ncbi.nlm.nih.gov/pubmed/22345664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102763
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